原著論文
Nakayama K, Obayashi Y, Munechika L, Kitamura SI, Yanagida T, Honjo M, Murakami S, Hirose E. 2024. Regeneration of the tunic cuticle is suppressed in the edible ascidian Halocynthia roretzi contracting soft tunic syndrome. Diseases of Aquatic Organism 159: 37–48.
https://doi.org/10.3354/dao03801Nakayama K & Kitamura SI. 2024. Susceptibility of common carp to the new ulcer disease-causing atypical Aeromonas salmonicida is temperature-dependent, but not body size-dependent. Fish Pathology 59: 29–32.
https://doi.org/10.3147/jsfp.59.29Nozaki K, Tanoue R, Kunisue T, Tue NM, Fujii S, Sudo N, Isobe T, Nakayama K, Sudaryanto A, Subramanian A, Bulbule KA, Parthasarathy P, Tuyen LH, Viet PH, Kondo M, Tanabe S, Nomiyama K. 2023. Pharmaceuticals and personal care products (PPCPs) in surface water and fish from three Asian countries: Species-specific bioaccumulation and potential ecological risks. Science of The Total Environment 866: 161258.
https://doi.org/10.1016/j.scitotenv.2022.161258Nakayama K, Tue NM, Fujioka N, Tokusumi H, Goto A, Uramaru N, Suzuki G. 2022. Determination of the relative potencies of brominated dioxins for risk assessment in aquatic environments using the early-life stage of Japanese medaka. Ecotoxicology and Environmental Safety, 247: 114227.
https://doi.org/10.1016/j.ecoenv.2022.114227Yanagida T, Nakayama K, Sawada T, Honjo M, Murakami S, Iida T, Hirose E, Kitamura SI. 2022. Innate immunity in the edible ascidian Halocynthia roretzi developing soft tunic syndrome: Hemolymph can eliminate the causative flagellates and discriminate allogeneic hemocytes. Fish & Shellfish Immunology, 127: 659–665.
https://doi.org/10.1016/j.fsi.2022.06.037Song JY, Kitamura SI, Oh MJ, Nakayama K. 2022. Heavy oil exposure suppresses antiviral activities in Japanese flounder Paralichthys olivaceus infected with viral hemorrhagic septicemia virus (VHSV). Fish & Shellfish Immunology, 124: 201–207.
https://doi.org/10.1016/j.fsi.2022.03.046Sawayama E, Tanizawa S, Nakayama K, Ito R, Akase Y, Kitamura SI. 2022. Major histocompatibility IIβ diversity and peptide-binding groove properties associated with red sea bream iridovirus resistance. Aquaculture, 552: 738038.
https://doi.org/10.1016/j.aquaculture.2022.738038仲山 慶，池田踏青，黒川大輔，北條裕也，宇野誠一．2022．魚類初期生活段階毒性試験の海産魚モデルとしてのクサフグの利用可能性について．環境毒性学会誌，25: 1–9.
https://doi.org/10.11403/jset.25.1Suzuki G, Matsukami H, Michinaka C, Hashimoto S, Nakayama K, Sakai SI. 2021. Emission of dioxin-like compounds and flame retardants from commercial facilities handling deca-BDE and their downstream sewage treatment plants. Environmental Science & Technology 55: 2324–2335.
https://doi.org/10.1021/acs.est.0c06359Tokusumi H, Fujioka N, Tue NM, Goto A, Suzuki G, Nakayama K. 2021. Toxicity testing of 2,3,7,8-tetrachlorodibenzo-p-dioxin in early-life stage of Japanese medaka: optimization of conditions for assessing relative potencies of dioxin-like compounds. Japanese Journal of Environmental Toxicology 24: 1–11.
https://doi.org/10.11403/jset.24.1Song JY, Casanova-Nakayama A, Möller AM, Kitamura SI, Nakayama K, Segner H. 2020. Aryl hydrocarbon receptor signaling is functional in immune cells of rainbow trout (Oncorhynchus mykiss). International Journal of Molecular Sciences 21: 6323.
https://doi.org/10.3390/ijms21176323宇野誠一，仲山 慶，橋本百花，河合兆治，國師恵美子．2019．ジャワメダカ胚を用いた広島湾底質のリスク影響評価．マリンエンジニアリング，54: 860–864.
https://doi.org/10.5988/jime.54.860Sawayama E, Kitamura SI, Nakayama K, Ohta K, Okamoto H, Ozaki A, Takagi M. 2019. Development of a novel RSIVD-resistant strain of red sea bream (Pagrus major) by marker-assisted selection combined with DNA-based family selection. Aquaculture 506: 188–192.
https://doi.org/10.1016/j.aquaculture.2019.03.039Kawaguchi M, Hagio H, Yamamoto N, Matsumoto K, Nakayama K, Akazome Y, Izumi H, Tsuneoka Y, Suto F, Murakami Y, Ichijo H. 2019. Atlas of the telencephalon based on cytoarchitecture, neurochemical markers, and gene expressions in Rhinogobius flumineus (Mizuno, 1960). Journal of Comparative Neurology 527: 874–900.
https://doi.org/10.1002/cne.24547Reza MAN, Mohapatra S, Shimizu S, Kitamura SI, Harakawa S, Kawakami H, Nakayama K, Sawayama E, Matsubara T, Ohta K, Chakrabortya T. 2018. Molecular cloning, characterization and expression analysis of complement components in red sea bream (Pagrus major) after Edwardsiella tarda and red sea bream Iridovirus (RSIV) challenge. Fish & Shellfish Immunology 82: 286–295.
https://doi.org/10.1016/j.fsi.2018.08.027Hirose E, Nakayama K, Yanagida T, Nawata A, Kitamura SI. 2018. Measurement of tunic hardness in an edible ascidian, Halocynthia roretzi, with remarks on soft tunic syndrome. Zoological Science 35: 548–553.
https://doi.org/10.2108/zs180072Sawayama E, Noguchi D, Nakayama K, Takagi M. 2018. Identification, characterization, and mapping of a novel SNP associated with body color transparency in juvenile red sea bream (Pagrus major). Marine Biotechnology 20: 481–489.
https://doi.org/10.1007/s10126-018-9810-zNarasaki Y, Ito S, Song JY, Obayashi Y, Nakayama K, Kitamura SI. 2018. Extracellular proteinases of Miamiensis avidus causing scuticociliatosis are potential virulence factors. Fish Pathology 53: 1–9.
https://doi.org/10.3147/jsfp.53.1Motokawa S, Narasaki Y, Song JY, Yokoyama Y, Hirose E, Murakami S, Jung SJ, Oh MJ, Nakayama K, Kitamura SI. 2018. Analysis of genes encoding high-antigenicity polypeptides in three serotypes of Miamiensis avidus. Parasitology International 67: 196–202.
https://doi.org/10.1016/j.parint.2017.10.007Sawayama E, Tanizawa S, Kitamura SI, Nakayama K, Ohta K, Ozaki A, Takagi M. 2017. Identification of quantitative trait loci for resistance to RSIVD in red sea bream (Pagrus major). Marine Biotechnology 19: 601–613.
https://doi.org/10.1007/s10126-017-9779-zItoyama T, Kawara M, Sugahara Y, Kurokawa D, Kawaguchi M, Fukui M, Kitamura SI, Nakayama K, Murakami Y. 2017. Nervous system disruption and swimming abnormality in early-hatched pufferfish (Takifugu niphobles) larvae caused by pyrene is independent of aryl hydrocarbon receptors. Marine Pollution Bulletin 124: 792–797.
https://doi.org/10.1016/j.marpolbul.2017.02.058Kitamura SI, Akizuki M, Song JY, Nakayama K. 2017. Tributyltin exposure increases mortality of nodavirus infected Japanese medaka Oryzias latipes larvae. Marine Pollution Bulletin 124: 835–838.
https://doi.org/10.1016/j.marpolbul.2017.02.020Nakayama K, Yamashita R, Kitamura SI. 2017. Use of common carp (Cyprinus carpio) and Aeromonas salmonicida for detection of immunomodulatory effects of chemicals on fish. Marine Pollution Bulletin 124: 710–713.
https://doi.org/10.1016/j.marpolbul.2016.12.060Chen K, Tsutsumi Y, Yoshitake S, Qiu X, Xu H, Hashiguchi Y, Honda M, Tashiro K, Nakayama K, Hano T, Suzuki N, Hayakawa K, Shimasaki Y, Oshima Y. 2017. Alteration of development and gene expression induced by in ovo-nanoinjection of 3-hydroxybenzo[c]phenanthrene into Japanese medaka (Oryzias latipes) embryos. Aquatic Toxicology 182: 194–204.
https://doi.org/10.1016/j.aquatox.2016.11.020Tasaki J, Nakayama K, Shimizu I, Yamada H, Suzuki T, Nishiyama N, Yamane M. 2017. Cellular and molecular hypoxic response in common carp (Cyprinus carpio) exposed to linear alkylbenzene sulfonate (LAS) at sub-lethal concentrations. Environmental Toxicology 32: 122–130.
https://doi.org/10.1002/tox.22217Nakayama K, Sato K, Shibano T, Isobe T, Suzuki G, Kitamura SI. 2016. Occurrence of glucocorticoids discharged from a sewage treatment plant in Japan and the effects of clobetasol propionate exposure on the immune responses of common carp (Cyprinus carpio) to bacterial infection. Environmental Toxicology and Chemistry 35: 946–952.
https://doi.org/10.1002/etc.3136Kimura K, Okuda S, Nakayama K, Shikata T, Takahashi F, Yamaguchi H, Sakamoto S, Yamaguchi M, Tomaru Y. 2015. RNA sequencing revealed numerous polyketide synthase genes in the harmful dinoflagellate Karenia mikimotoi. PLOS ONE 10: e0142731.
https://doi.org/10.1371/journal.pone.0142731Kimura S, Nakayama K, Wada M, Kim U, Azumi K, Ojima T, Nozawa A, Kitamura SI, Hirose E. 2015. Cellulose is not degraded in the tunic of the edible ascidian Halocynthia roretzi contracting soft tunic syndrome. Diseases of Aquatic Organisms 116: 143–148.
https://doi.org/10.3354/dao02913Suzuki G, Sato K, Isobe T, Takigami H, Brouwer A, Nakayama K. 2015. Detection of glucocorticoid receptor agonists in effluents from sewage treatment plants in Japan. Science of the Total Environment 527–528: 328–334.
https://doi.org/10.1016/j.scitotenv.2015.05.008Isobe T, Sato K, Kim JW, Tanabe S, Suzuki G, Nakayama K. 2015. Determination of natural and synthetic glucocorticoids in effluent of sewage treatment plants using ultrahigh performance liquid chromatography-tandem mass spectrometry. Environmental Science and Pollution Research 22: 14127–14135.
https://doi.org/10.1007/s11356-015-4626-0Sugahara Y, Kawaguchi M, Itoyama T, Kurokawa D, Tosa Y, Kitamura SI, Handoh IC, Nakayama K, Murakami Y. 2014. Pyrene induces a reduction in midbrain size and abnormal swimming behavior in early-hatched pufferfish larvae. Marine Pollution Bulletin 85: 479–486.
https://doi.org/10.1016/j.marpolbul.2014.04.022Nakayama K, Inoue Y, Ikeda N, Hashizume N, Murakami H, Ishibashi T, Ikeda H, Isobe T, Kitamura SI, Suzuki G. 2014. Uptake and biological effects of synthetic glucocorticoids in common carp (Cyprinus carpio). Marine Pollution Bulletin 85: 370–375.
https://doi.org/10.1016/j.marpolbul.2014.01.042Niimi S, Imoto M, Kunisue T, Watanabe MX, Kim E-Y, Nakayama K, Yasunaga G, Fujise Y, Tanabe S, Iwata H. 2014. Effects of persistent organochlorine exposure on the liver transcriptome of the common minke whale (Balaenoptera acutorostrata) from the North Pacific. Ecotoxicology and Environmental Safety 108: 95–105.
https://doi.org/10.1016/j.ecoenv.2014.06.028Iwakiri S, Song JY, Nakayama K, Oh MJ, Ishida M, Kitamura SI. 2014. Host responses of Japanese flounder Paralichthys olivaceus with lymphocystis cell formation. Fish & Shellfish Immunology 38: 406–411.
https://doi.org/10.1016/j.fsi.2014.03.028Uno S, Shintoyo A, Kokushi E, Yamamoto M, Nakayama K, Koyama J. 2012. Gas chromatography-mass spectrometry for metabolite profiling of Japanese medaka (Oryzias latipes) juveniles exposed to malathion. Environmental Science and Pollution Research 19: 2595–2605.
https://doi.org/10.1007/s11356-012-0834-zKawaguchi M, Sugahara Y, Watanabe T, Irie K, Ishida M, Kurokawa D, Kitamura SI, Tanaka H, Handoh IC, Nakayama K, Murakami Y. 2012. Nervous system disruption and concomitant behavioral abnormality in early-hatched pufferfish larvae exposed to heavy oil. Environmental Science and Pollution Research 19: 2488–2497.
https://doi.org/10.1007/s11356-012-0833-0Song JY, Ohta S, Nakayama K, Murakami Y, Kitamura SI. 2012. A time-course study of immune response in Japanese flounder Paralichthys olivaceus exposed to heavy oil. Environmental Science and Pollution Research 19: 2300–2304.
https://doi.org/10.1007/s11356-012-0737-zSong JY, Nakayama K, Kokushi E, Ito K, Uno S, Koyama J, Rahman MH, Murakami Y, Kitamura SI. 2012. Effect of heavy oil exposure on antibacterial activity and expression of immune-related genes in Japanese flounder Paralichthys olivaceus. Environmental Toxicology and Chemistry 31: 828–835.
https://doi.org/10.1002/etc.1743Irie K, Kawaguchi M, Mizuno K, Song JY, Nakayama K, Kitamura SI, Murakami Y. 2011. Effect of heavy oil on the development of the nervous system of floating and sinking teleost eggs. Marine Pollution Bulletin 63: 297–302.
https://doi.org/10.1016/j.marpolbul.2011.04.018Song JY, Nakayama K, Murakami Y, Kitamura SI. 2011. Heavy oil exposure induces high mortalities in virus carrier Japanese flounder Paralichthys olivaceus. Marine Pollution Bulletin 63: 362–365.
https://doi.org/10.1016/j.marpolbul.2011.01.020Kawaguchi M, Song JY, Irie K, Murakami Y, Nakayama K, Kitamura SI. 2011. Disruption of Sema3A expression causes abnormal neural projection in heavy oil exposed Japanese flounder larvae. Marine Pollution Bulletin 63: 356–361.
https://doi.org/10.1016/j.marpolbul.2011.01.022Isobe T, Oshihoi T, Hamada H, Nakayama K, Yamada TK, Tajima Y, Amano M, Tanabe S. 2011. Contamination status of POPs and BFRs and relationship with parasitic infection in finless porpoises (Neophocaena phocaenoides) from Seto Inland sea and Omura bay, Japan. Marine Pollution Bulletin 63: 564–571.
https://doi.org/10.1016/j.marpolbul.2011.01.014Nakayama K, Sei N, Handoh IC, Shimasaki Y, Honjo T, Oshima Y. 2011. Effects of polychlorinated biphenyls on liver function and sexual characteristics in Japanese medaka (Oryzias latipes). Marine Pollution Bulletin 63: 366–369.
https://doi.org/10.1016/j.marpolbul.2011.01.015Hirakawa S, Imaeda D, Nakayama K, Udaka M, Kim E-Y, Kunisue T, Ogawa M, Matsuda T, Matsui S, Petrov EA, Batoev VB, Tanabe S, Iwata H. 2011. Integrative assessment of potential effects of dioxins and related compounds in wild Baikal seals (Pusa sibirica): Application of microarray and biochemical analyses. Aquatic Toxicology 105: 89–99.
https://doi.org/10.1016/j.aquatox.2011.05.007Nassef M, Tawaratsumita T, Oba Y, Satone H, Nakayama K, Shimasaki Y, Honjo T, Oshima Y. 2011. Induction of tributyltin-binding protein type 2 in Japanese flounder, Paralichthys olivaceus, by exposure to tributyltin-d27. Marine Pollution Bulletin 62: 412–414.
https://doi.org/10.1016/j.marpolbul.2010.12.005Nassef M, Kato-Unoki Y, Furuta T, Nakayama K, Satone H, Shimasaki Y, Honjo T, Oshima Y. 2011. Molecular cloning, sequencing, and gene expression analysis of tributyltin-binding protein type 1 in Japanese medaka fish, Oryzias latipes. Zoological Science 28: 281–285.
https://doi.org/10.2108/zsj.28.281Nakayama K, Handoh IC, Kitamura S-I, Kim E-Y, Iwata H, Tanabe S. 2010. A microarray data analysis method to evaluate the impact of contaminants on wild animals. Science of the Total Environment 408: 5824–5827.
https://doi.org/10.1016/j.scitotenv.2010.08.065Nakayama K, Matsudaira C, Tajima Y, Yamada TK, Yoshioka M, Isobe T, Takahashi S, Tanabe S. 2009. Temporal and spatial trends of organotin contamination in the livers of finless porpoises (Neophocaena phocaenoides) and their association with parasitic infection status. Science of the Total Environment 407: 6173–6178.
https://doi.org/10.1016/j.scitotenv.2009.08.043Song J-Y, Sasaki K, Okada T, Kawakami H, Matsuoka S, Kang H-S, Nakayama K, Jung S-J, Oh M-J, Kitamura S-I. 2009. Antigenic differences of the scuticociliate Miamiensis avidus from Japan. Journal of Fish Diseases 32: 1027–1034.
https://doi.org/10.1111/j.1365-2761.2009.01089.x仲山 慶，酒井大樹，北村真一，須藤明子，金 恩英，田辺信介，岩田久人．2008．カワウ野生個体と培養細胞における遺伝子発現プロファイルの比較．環境毒性学会誌，11: 75–81.
https://doi.org/10.11403/jset.11.75Nakayama K, Iwata H, Tao L, Kannan K, Imoto M, Kim E-Y, Tashiro K, Tanabe S. 2008. Potential effects of perfluorinated compounds in common cormorants from Lake Biwa, Japan: an implication from the hepatic gene expression profiles by microarray. Environmental Toxicology and Chemistry 27: 2378–2386.
https://doi.org/10.1897/07-614.1Zhang X, Hecker M, Park J-W, Tompsett AR, Newsted J, Nakayama K, Jones PD, Au D, Kong R, Wu RSS, Giesy JP. 2008. Real time PCR array to study effects of chemicals on the hypothalamic-pituitary-gonadal axis of the Japanese medaka. Aquatic Toxicology 88: 173–182.
https://doi.org/10.1016/j.aquatox.2008.04.009Song J-Y, Nakayama K, Murakami Y, Jung S-J, Oh M-J, Matsuoka S, Kawakami H, Kitamura S-I. 2008. Does heavy oil pollution induce bacterial diseases in Japanese flounder Paralichthys olivaceus? Marine Pollution Bulletin 57: 889–894.
https://doi.org/10.1016/j.marpolbul.2008.01.024Murakami Y, Kitamura S-I, Nakayama K, Matsuoka S, Sakaguchi H. 2008. Effects of heavy oil in the developing spotted halibut, Verasper variegates. Marine Pollution Bulletin 57: 524–528.
https://doi.org/10.1016/j.marpolbul.2008.02.043Nakayama K, Sei N, Oshima Y, Tashiro K, Shimasaki Y, Honjo T. 2008. Alteration of gene expression profiles in the brain of Japanese medaka (Oryzias latipes) exposed to KC-400 or PCB126. Marine Pollution Bulletin 57: 460–466.
https://doi.org/10.1016/j.marpolbul.2008.02.020Nakayama K, Kitamura S-I, Murakami Y, Song J-Y, Jung S-J, Oh M-J, Iwata H, Tanabe S. 2008. Toxicogenomic analysis of immune system-related genes in Japanese flounder (Paralichthys olivaceus) exposed to heavy oil. Marine Pollution Bulletin 57: 445–452.
https://doi.org/10.1016/j.marpolbul.2008.02.021Shimasaki Y, Oshima Y, Inoue Y, Shibata H, Nakayama K, Inoue S, Imoto H, Kang I-J, Honjo T. 2008. Distribution of tributyltin in tissues of mature Japanese whiting, Sillago japonica and their eggs. Journal of Faculty of Agriculture, Kyushu University 53: 67–72.
https://doi.org/10.5109/10073大嶋雄治，堀 就英，井上 英，橋本伸哉，仲山 慶，島崎洋平，甲斐徳久，本城凡夫．2008．粉砕脱水法による魚肉からのCo-PCBsの除去．九大農学芸誌，63，41-45．
https://doi.org/10.15017/9849Nakayama K, Oshima Y, Tachibana T, Furuse M, Honjo T. 2007. Alteration of monoamine concentrations in the brain of medaka, Oryzias latipes, exposed to tributyltin. Environmental Toxicology 22: 53–57.
https://doi.org/10.1002/tox.20233Shimasaki Y, Oshima Y, Inoue S, Inoue Y, Kang I-J, Nakayama K, Imoto H, Honjo T. 2006. Effect of tributyltin on reproduction in Japanese whiting, Sillago japonica. Marine Environmental Research 62 (Suppl 1): S245–S248.
https://doi.org/10.1016/j.marenvres.2006.04.030Nakayama K, Iwata H, Kim E-Y, Tashiro K, Tanabe S. 2006. Gene expression profiling in common cormorant liver with an oligo array: assessing the potential toxic effects of environmental contaminants. Environmental Science & Technology 40: 1076–1083.
https://doi.org/10.1021/es051386mNakayama K, Oshima Y, Hiramatsu K, Shimasaki Y, Honjo T. 2005. Effects of polychlorinated biphenyls on the schooling behavior of Japanese medaka, Oryzias latipes. Environmental Toxicology & Chemistry 24: 2588–2593.
https://doi.org/10.1897/04-518R2.1Nakayama K, Oshima Y, Nagafuchi K, Hano T, Shimasaki Y, Honjo T. 2005. Early–life-stage toxicity in offspring from exposed parent medaka, Oryzias latipes, to mixtures of tributyltin and polychlorinated biphenyls. Environmental Toxicology & Chemistry 24: 591–596.
https://doi.org/10.1897/04-157R.1Oshima Y, Takeda T, Katayama S, Inoue Y, Inoue S, Nakayama K, Shimasaki Y, Honjo T. 2004. Relationship between temperature and pharmacokinetic parameters of florfenicol in carp (Cyprinus carpio). Japanese Journal of Environmental Toxicology 7: 61–68.
https://doi.org/10.11403/jset.7.61Oshima Y, Koyama J, Nakayama K, Inoue Y, Shimasaki Y, Inoue S, Honjo T. 2004. Use of hepatic CYP1A1 activity in Japanese flounder to monitor oil dispersed from the Nakhodka spill. Japanese Journal of Environmental Toxicology 7: 123–129.
https://doi.org/10.11403/jset.7.123Nakayama K, Oshima Y, Hiramatsu K, Honjo T. 2004. Alteration of general behavior of male medaka, Oryzias latipes, exposed to tributyltin and/or polychlorinated biphenyls. Journal of Faculty of Agriculture, Kyushu University 49: 85–92.
https://doi.org/10.5109/4568Nakayama K, Oshima Y, Yamaguchi T, Tsuruda Y, Kang I-J, Kobayashi M, Imada N, Honjo T. 2004. Fertilization success and sexual behavior in male medaka, Oryzias latipes, exposed to tributyltin. Chemosphere 55: 1331–1337.
https://doi.org/10.1016/j.chemosphere.2003.11.050Omura M, Shimasaki Y, Oshima Y, Nakayama K, Kubo K, Aou S, Ogata R, Hirata M, Inoue N. 2004. Distribution of tributyltin, dibutyltin and monobutyltin in the liver, brain and fat of rats: two-generation toxicity study of tributyltin chloride. Environmental Sciences 11: 123–132.
Oshima Y, Kang I-J, Kobayashi M, Nakayama K, Imada N, Honjo T. 2003. Suppression of sexual behavior in male Japanese medaka (Oryzias latipes) exposed to 17beta-estradiol. Chemosphere 50: 429–436.
https://doi.org/10.1016/S0045-6535(02)00494-0